10406-25-4, name is 4-(Aminomethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 10406-25-4
General procedure: Biphenyl-3-carboxylic acid (500mg, 2.52mmol) and 4-aminomethyl-benzonitrile (425mg, 2.52mmol) were suspended in DCM (25mL) and DIPEA (873uL, 5.04mmol), EDC (484mg, 2.52mmol) and HOBt (386mg, 2.52mmol) were added. The reaction mixture was stirred overnight, concentrated in vacuo and partitioned between EtOAc (lOOmL) and water (lOOmL). The organic fraction was washed with water (l OOmL), sat aq NaHCC>3 (50mL), brine (50mL), dried (MgSC ) and concentrated in vacuo to give the title compound (738mg, 94%) as a brown solid. LCMS: ES+ 313.0 [MH]+.
Statistics shows that 10406-25-4 is playing an increasingly important role. we look forward to future research findings about 4-(Aminomethyl)benzonitrile.
Reference:
Patent; PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher; HIGGINBOTTOM, Michael; WO2014/20350; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts