In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6393-40-4 as follows. 6393-40-4
Step 1: 4-Amino-3-nitrobenzothioamide (220) [0371] To a stirred solution of 219 (1.96 g, 12.02 MMOL) in pyridine (15 mL) and Et3N (6ML) was bubbled hydrogen sulfide for 40 minutes. When the reaction was completed nitrogen was bubbled for another 40 min. The residue was diluted in DCM and washed with water, HCI 10% and brine. Organic phases were collected, dried with sodium sulfate and concentrated under reduced pressure to afford the title compound 220 (2.11 g, 89% YIELD). 1H NMR: (DMSO) 8 (ppm): 9.04 (BS, 1H), 8.31 (d, J=9.2 Hz, 1H), 7.28 (d, J=8.8 Hz, 1H). MS: (CALC.) 197.2 ; (obt. ) 198. KM) .
According to the analysis of related databases, 6393-40-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; METHYLGENE, INC.; WO2005/30704; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts