In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16532-79-9, name is 4-Bromophenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 16532-79-9
Bromobenzeneacetonitrile (I) 0.97 g (5 mmol),1.73 g (6 mmol) of 4-boronic acid triphenylamine,Tetrakis (triphenylphosphine) palladium 0.11 g (0.1 mmol) was dissolved in a mixed solution of toluene 45 mL / tetrahydrofuran 35 mL,Aqueous sodium carbonate (2.0 M, 5 mL) was added.Under a nitrogen atmosphere,Heating to 90 reaction 36h.The reaction liquid was cooled,After evaporating the solvent under reduced pressure,Extraction with dichloromethane (60 mL x 3)The combined organic phase,Respectively, saturated aqueous sodium carbonate solution and saturated brine,Finally, dry over anhydrous magnesium sulfate.filter,The filtrate was concentrated under reduced pressure,The residue was separated by silica gel column chromatography,The eluent is a mixed solvent of petroleum ether / ethyl acetate in a volume ratio of 45/1,Collect the eluate containing the target compound,After the solvent was removed under reduced pressure and dried,1.62 g of the yellow powder triphenylamine intermediate (IV)The yield is 90%.
The synthetic route of 16532-79-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Huzhou Normal College; Zhang Yujian; Zhang Qi; Yang Heyi; Qi Jun; Cao Feng; Zhang Cheng; (12 pag.)CN106883168; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts