Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1835-65-0, name is 3,4,5,6-Tetrafluorophthalonitrile, A new synthetic method of this compound is introduced below., 1835-65-0
SYNTHESIS EXAMPLE 6 Synthesis of 3-(2,6-dimethylphenoxy)-4,5-bis(phenylthio)-6-fluorophthalonitrile In a four-neck separable flask having an inner volume of 500 ml, 60 g (0.30 mol) of tetrafluorophthalonitrile, 41.8 g (0.72 mol) of potassium fluoride, and 160 ml of acetone were placed. Further, in a dropping funnel attached thereto, 33.0 g (0.60 mol) of thiophenol was charged. The thiophenol from the dropping funnel was added dropwise from the dropping funnel while kept stirred, with the speed of dropping adjusted so as to keep the reaction temperature of not more than 40¡ã C. and the stirring was subsequently continued for about two hours. Then, to this flask, 40.3 g (0.33 mol) of 2,6-dimethylphenol, 20.9 g (0.36 mol) of potassium fluoride, and 40 ml of acetonitrile were charged. The mixture was kept stirred under reflux for 8 hours. The reaction solution was cooled and filtered. The filtrate was washed with 600 ml of acetonitrile and filtered. The combined filtrate was distilled by a rotary evaporator to expel the acetonitrile and was recrystallized from methanol. The produced crystals were separated by filtration and vacuum dried to afford 113.8 g of 3-(2,6-dimethylphenoxy)-4,5-bis(phenylthio)-6-fluorophthalonitrile (yield: 78.6 mol percent).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Nippon Shobukai Co., Ltd.; US6323340; (2001); B1;,
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