These common heterocyclic compound, 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 622-75-3
Synthesis of PIDSB: PIDSB was prepared by knoevenagel condensation reaction.In a 100 mL round bottom flask, PICHO(8mmol, 3.18g),The p-benzenediacetonitrile (4 mmol, 0.63 g) was dissolved in 50 mL of tetrahydrofuran and 25 ml of t-butanol, and the temperature was raised to 46 C under a nitrogen atmosphere.1 ml of tetrabutylammonium hydroxide (TBAH) and a solution of 80 mg of potassium t-butoxide in tetrahydrofuran were prepared in advance.After half an hour of reaction, the system was poured into acetic acidified methanol solution at room temperature.The crude product was obtained by suction filtration and separated by column chromatography ( petroleum ether: methylene chloride = 1:5,The volume ratio) gave a red powdery solid (1.96 g, yield: 53%).Mass spectrum MALDI-TOF (m/z) [M+]: The found value was 917.56 and the theoretical value was 916.33.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 622-75-3.
Reference:
Patent; Jilin University; Lu Ping; Sun Xiaoyi; Li Jinyu; (13 pag.)CN108822040; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts